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Article

Generation of pancreatic progenitors from human pluripotent stem cells by small molecules

26 Aug 2021

Abstract excerpt

Human pluripotent stem cell (hPSC)-derived pancreatic progenitors (PPs) provide promising cell therapies for type 1 diabetes. Current PP differentiation requires a high amount of Activin A during the definitive endoderm (DE) stage, making it economically difficult for commercial ventures. Here we identify a dose-dependent role for Wnt signaling in controlling DE differentiation without Activin A. While high-level...

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PMID: 34450037
DOI: 10.1016/j.stemcr.2021.07.021

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