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Article

Endodermal differentiation of human pluripotent stem cells to insulin-producing cells in 3D culture.

Scientific reports - 27 Mar 2014

Takeuchi Hiroki, Nakatsuji Norio, Suemori Hirofumi

Abstract excerpt

Insulin-producing cells (IPCs) derived from human pluripotent stem cells (hPSCs) may be useful in cell therapy and drug discovery for diabetes. Here, we examined various growth factors and small molecules including those previously reported to develop a robust differentiation method for induction of mature IPCs from hPSCs. We established a protocol that induced PDX1-positive pancreatic progenitor cells at high...

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Cell Culture Techniques
Endoderm
Immunophenotyping
Insulin
Insulin-Secreting Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pluripotent Stem Cells

Receptor, Transforming Growth Factor-beta Type I

Receptors, Transforming Growth Factor beta

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Identifiers

PMID: 24671046
DOI: 10.1038/srep04488
PMCID: PMC3967149

Genes

PDX1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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