Article

Generation of gastric insulin-secreting organoids from human stomach sample

2023-04-27

Abstract excerpt

<title>Abstract</title> <p>Stomach stem cells are accessible by biopsy and propagate robustly in culture, offering an invaluable resource for autologous cell therapies. Here we describe a detailed protocol to isolate, expand, engineer and differentiate human gastric stem cells (hGSCs) into pancreatic islet-like organoids containing abundant gastric insulin-secreting (GINS) cells that resemble beta-cells in molecu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a8791cc2-68cd-55cb-8324-02f7feeada4d
DOI: 10.21203/rs.3.pex-2147/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Generation of gastric insulin-secreting organoids from human stomach sampleDOI 10.21203/rs.3.pex-2147/v1Read

Restoring glucose homeostasis with stomach-derived human insulin-secreting organoidsSemantic proximity Read

Generation and long-term expansion of human pancreatic islet organoids <i>in vitro</i>Semantic proximity Read

Generation of Insulin-Producing Islet-Like Clusters from Human Embryonic Stem CellsSemantic proximity Read

Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cellsSemantic proximity Read

Pancreatic Endoderm-Derived From Diabetic Patient-Specific Induced Pluripotent Stem Cell Generates Glucose-Responsive Insulin-Secreting Cells.Semantic proximity Read

Expansion and Differentiation of Adult Human Pancreas-Derived Progenitor Cells into Functional Islet-Like OrganoidsSemantic proximity Read

A perfect islet: reviewing recent protocol developments and proposing strategies for stem cell derived functional pancreatic isletsSemantic proximity Read

Forward programming of hiPSCs towards beta-like cells using Ngn3, Pdx1, and MafASemantic proximity Read

Islet organoid as a promising model for diabetesSemantic proximity Read

Novel MAFA+, ISL1+, NKX6-1-stem cell derived pancreatic cell clusters secrete insulin and control blood glucose in rodent models of diabetesSemantic proximity Read

Single-Cell Transcriptome Profiling of Mouse and hESC-Derived Pancreatic ProgenitorsSemantic proximity Read

Gastric Stem Cells: Physiological and Pathological PerspectivesSemantic proximity Read