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Generating pancreatic β-cells from embryonic stem cells by manipulating signaling pathways

12 Apr 2010

Abstract excerpt

Type 1 diabetes results from an insufficiency of insulin production as a result of autoimmune destruction of the insulin-secreting pancreatic beta-cells. It can be treated by transplantation of islets of Langerhans from human donors, but widespread application of this therapy is restricted by the scarcity of donor tissue. Generation of functional beta-cells from embryonic stem (ES) cells in vitro could provide a...

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PMID: 20385725
DOI: 10.1677/joe-10-0073

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