Article

Restoring glucose homeostasis with stomach-derived human insulin-secreting organoids

2022-12-16

Abstract excerpt

<h4>ABSTRACT</h4> Gut stem cells are accessible by biopsy and propagate robustly in culture, offering an invaluable resource for autologous cell therapies. Insulin-producing cells can be induced in mouse gut, but it has not been possible to generate abundant and durable insulin-secreting cells from human gut tissues to evaluate their potential as a cell therapy for diabetes. Here we describe a protocol to differe...

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Literature Corpus work: 4f65cf2c-2ee2-5a50-893f-1edcfd7d3db9
DOI: 10.1101/2022.12.15.520488

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