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A high-content small molecule screen identifies novel inducers of definitive endoderm

4 May 2017

Abstract excerpt

OBJECTIVES: Human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) can generate any given cell type in the human body. One challenge for cell-replacement therapy is the efficient differentiation and expansion of large quantities of progenitor cells from pluripotent stem cells produced under good manufacturing practice (GMP). FOXA2 and SOX17 double positive definitive endoderm (DE)...

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PMID: 28702321
DOI: 10.1016/j.molmet.2017.04.009

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