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An Update on Animal Models of Osteogenesis Imperfecta.

Calcified tissue international - 1 Oct 2022

Lv Fang, Cai Xiaoling, Ji Linong

Abstract excerpt

Osteogenesis imperfecta (OI) is a heterogeneous disorder characterized by bone fragility, multiple fractures, bone deformity, and short stature. In recent years, the application of next generation sequencing has triggered the discovery of many new genetic causes for OI. Until now, more than 25 genetic causes of OI and closely related disorders have been identified. However, the mechanisms of many genes on...

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PMID: 35767009
DOI: 10.1007/s00223-022-00998-6

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