Article

A CRISPR/Cas9-generated mutation in the zebrafish orthologue of PPP2R3B causes idiopathic scoliosis

2022-12-07

Abstract excerpt

Idiopathic scoliosis (IS) is the deformation and/or abnormal curvature of the spine that develops progressively after birth. It is a very common condition, affecting approximately 4% of the general population, yet the genetic and mechanistic causes of IS are poorly understood. Here, we focus on PPP2R3B, which encodes a protein phosphatase 2A regulatory subunit that has been linked to regulation of autophagy. We fo...

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Literature Corpus work: 772aa853-77b8-5513-9de4-623ba54c8ea6
DOI: 10.21203/rs.3.rs-2276950/v1

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