Article

Tendon and Motor Phenotypes in the <i> Crtap <sup>-/-</sup> </i> Mouse Model of Recessive Osteogenesis Imperfecta

2020-04-22

Abstract excerpt

<h4>ABSTRACT</h4> Osteogenesis imperfecta (OI) is characterized by short stature, skeletal deformities, low bone mass with bone fragility, and motor deficits. A subset of OI patients also present with joint hypermobility; however, the role of tendon/ligament dysfunction in OI pathogenesis is largely unknown. Using the Crtap -/- mouse model of severe, recessive OI, we found that mutant Achilles tendons and patell...

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Literature Corpus work: a43a3a59-300d-5019-ad4d-756884f9e7e5
DOI: 10.1101/2020.04.21.048488

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