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Macon: Enhance Protein Mutation Representation using Contrastive Learning with Effect Prediction on Protein–protein Interactions

2025-10-09

Abstract excerpt

<title>Abstract</title> <p>Mutations in protein sequences can significantly alter protein-protein interactions (PPIs), leading to diverse functional outcomes relevant to disease mechanisms and therapeutic targeting. While existing computational approaches predominantly estimate changes in binding free energy in PPIs, they often failed to capture categorical effects such as complete disruption of interaction or ga...

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Literature Corpus work: a346165d-f20a-5c2d-89dd-4b947b7aee13
DOI: 10.21203/rs.3.rs-7469880/v1

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