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Article

DeepPNI: a language- and graph-based model for mutation-driven protein-nucleic acid binding energetics.

Nucleic acids research - 10 Aug 2026

Mondal Somnath, Mondal Tinkal, Pramanik Soumajit, Mehra Rukmankesh

Abstract excerpt

Protein-nucleic acid interactions (PNIs) are central to fundamental biological processes, and mutations can disrupt these interactions by altering local structural features and binding free energy. Here, we present DeepPNI, a deep learning regression model that integrates sequence- and structure-based features to estimate mutation-induced changes in binding free energy in protein-nucleic acid complexes. The model...

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PMID: 42605800
DOI: 10.1093/nar/gkag820
PMCID: PMC13478755

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