Article

Sequence-aware Prediction of Point Mutation-induced Effects on Protein-Protein Binding Affinity using Deep Learning

2025-11-16

Abstract excerpt

<h4>ABSTRACT</h4> Amino acid mutations may lead to significant changes in the binding affinity of protein complexes, thereby causing a series of cellular dysfunctions. Therefore, accurate prediction of protein-protein binding affinity changes (ΔΔG) induced by amino acid mutations is of great importance for understanding protein-protein interactions (PPIs). In this study, we propose SAMAffinity, a protein sequence...

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Literature Corpus work: 976ba32e-34aa-558f-aa2b-e8e1dea2d2e0
DOI: 10.1101/2025.11.15.688659

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