Article

Inferring the effects of protein variants on protein–protein interactions with an interpretable deep-learning model

2022-11-22

Abstract excerpt

<title>Abstract</title><p>Identifying pathogenetic variants and inferring their impact on protein–protein interactions sheds light on their functional consequences on diseases. Limited by the availability of experimental data on the consequences on protein interaction, most existing methods focus on building models to predict changes in protein binding affinity. Here, we introduced MIPPI, an end-to-end, interpreta...

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Literature Corpus work: ccde6198-cc39-5ac3-94a7-d2543fe29779
DOI: 10.21203/rs.3.rs-2300902/v1

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