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Article

ProBASS-a language model with sequence and structural features for predicting the effect of mutations on binding affinity.

Bioinformatics (Oxford, England) - 6 May 2025

Gurusinghe Sagara N S, Wu Yibing, DeGrado William, Shifman Julia M

Abstract excerpt

MOTIVATION: Protein-protein interactions (PPIs) govern virtually all cellular processes, and a single mutation within a PPI can significantly impact protein functionality, potentially leading to diseases. While numerous approaches have emerged to predict changes in the free energy of binding due to mutations (ΔΔGbind), most lack precision. Recently, protein language models (PLMs) have shown powerful predictive...

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Topics

Mutation
Protein Binding
Proteins
Software
Thermodynamics
Computational Biology
Models, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Protein Conformation

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Identifiers

PMID: 40343467
DOI: 10.1093/bioinformatics/btaf270
PMCID: PMC12151015

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