Article

Mutation effect estimation on protein-protein interactions using deep contextualized representation learning

2019-12-15

Abstract excerpt

The functional impact of protein mutations is reflected on the alteration of conformation and thermodynamics of protein-protein interactions (PPIs). Quantifying the changes of two interacting proteins upon mutations are commonly carried out by computational approaches. Hence, extensive research efforts have been put to the extraction of energetic or structural features on proteins, followed by statistical learning...

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Literature Corpus work: 93da2eb5-43bf-597a-b6e9-321a9f61a51a
DOI: 10.1101/2019.12.15.876953

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