Article

ESM-Effect: An Effective and Efficient Fine-Tuning Framework towards accurate prediction of Mutation’s Functional Effect

2025-02-07

Abstract excerpt

Predicting functional properties of mutations like the change in enzyme activity remains challenging and is not well captured by traditional pathogenicity prediction. Yet such functional predictions are crucial in areas like targeted cancer therapy where some drugs may only be administered if a mutation causes an increase in enzyme activity. Current approaches either leverage static Protein-Language Model (PLM) em...

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Literature Corpus work: cf88a9c3-e080-5e0d-adff-9b0af11e68f8
DOI: 10.1101/2025.02.03.635741

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