Article

eSIG-Net: Accurate prediction of single-mutation induced perturbations on protein interactions using a language model

2026-03-31

Abstract excerpt

Most proteins exert their functions in complex with other interactors. Single mutations can exhibit a profound impact on perturbing protein interactions, leading to human disease. However, predicting the effect of single mutations on protein interactions remains a major computational challenge. Deep learning, particularly protein language models or transformers, has become an effective tool in bioinformatics for p...

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Literature Corpus work: 5ee80fe5-9d48-5072-ab51-8145d08c952a
DOI: 10.64898/2026.03.27.714913

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