Article

ProBASS – a language model with sequence and structural features for predicting the effect of mutations on binding affinity

2024-06-26

Abstract excerpt

Protein-protein interactions (PPIs) govern virtually all cellular processes. Even a single mutation within PPI can significantly influence overall protein functionality and potentially lead to various types of diseases. To date, numerous approaches have emerged for predicting the change in free energy of binding (ΔΔG bind ) resulting from mutations, yet the majority of these methods lack precision. In recent year...

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Literature Corpus work: de3c85b9-8db2-5c4b-8a5b-16034a59c564
DOI: 10.1101/2024.06.21.600041

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