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Article

MutPPI+: a multimodal framework for predicting mutation effects on protein-protein interactions via mutation-path-based data augmentation.

Briefings in bioinformatics - 1 Mar 2026

Deng Juntao, Gu Miao, Zhang Pengyan, Liu Tao, Hu Guansong, Dong Mingyu, Zhang Yabin, Song Yizhen, Zhang Yunfan, Liu Min, Tian Junzhang, Cheng Weibin

Abstract excerpt

Protein-protein interactions (PPIs) are central to cellular signaling and regulation, and their dysregulation underlies many diseases. Predicting the impact of mutations on PPI stability, quantified as ΔΔG, is essential for understanding disease mechanisms and guiding protein engineering. Here, we first present MutPPI, a graph-based deep-learning model that encodes full-residue structural features of...

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Computational Biology
Databases, Protein
Deep Learning
Mutation
Protein Interaction Mapping

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Protein Interaction Maps

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PMID: 41795656
DOI: 10.1093/bib/bbag105
PMCID: PMC12967331

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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