Article

Quantifying B-cell Clonal Diversity In Repertoire Data

2022-12-14

Abstract excerpt

The adaptive immune system has the extraordinary ability to produce a broad range of immunoglobulins that can bind a wide variety of antigens. During adaptive immune responses, activated B cells duplicate and undergo somatic hypermutation in their B-cell receptor (BCR) genes, resulting in clonal families of diversified B-cells that can be related back to a common ancestor. Advances in high-throughput sequencing te...

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Literature Corpus work: a33b9a8b-c65f-5a95-990c-38611ec13343
DOI: 10.1101/2022.12.12.520133

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