Article

Nef Dimerization Defect Abrogates HIV Viremia and Associated Immune Dysregulation in the Bone Marrow-Liver-Thymus-Spleen (BLTS) Humanized Mouse Model.

2021-03-18

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>Loss of function mutations in the human immunodeficiency virus (HIV) negative factor (<italic>nef</italic>) gene are associated with reduced viremia, robust T cell immune responses, and delayed acquired immunodeficiency syndrome (AIDS) progression in humans. Importantly, Nef persists in antiretroviral therapy-treated chronic HIV-infected individuals. <italic>In vi...

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Literature Corpus work: a333febb-02dc-5a7b-bf5c-77cbb28b50b9
DOI: 10.21203/rs.3.rs-297149/v1

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