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Article

Nef functions in BLT mice to enhance HIV-1 replication and deplete CD4+CD8+ thymocytes

28 May 2012

Abstract excerpt

BACKGROUND: The outcome of untreated HIV-1 infection is progression to AIDS and death in nearly all cases. Some important exceptions are the small number of patients infected with HIV-1 deleted for the accessory gene, nef. With these infections, disease progression is entirely suppressed or greatly delayed. Whether Nef is critical for high levels of replication or is directly cytotoxic remains controversial. The...

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PMID: 22640559
DOI: 10.1186/1742-4690-9-44

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