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Article

In vivo analysis of highly conserved Nef activities in HIV-1 replication and pathogenesis

30 Oct 2013

Abstract excerpt

BACKGROUND: The HIV-1 accessory protein, Nef, is decisive for progression to AIDS. In vitro characterization of the protein has described many Nef activities of unknown in vivo significance including CD4 downregulation and a number of activities that depend on Nef interacting with host SH3 domain proteins. Here, we use the BLT humanized mouse model of HIV-1 infection to assess their impact on viral replication...

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PMID: 24172637
DOI: 10.1186/1742-4690-10-125

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