Article
Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice.
Cell - 16 Oct 1998
Hanna Z, Kay D G, Rebai N, Guimond A, Jothy S, Jolicoeur P
Abstract excerpt
Transgenic (Tg) mice expressing the complete coding sequences of HIV-1 in CD4+ T cells and in cells of the macrophage/dendritic lineages develop severe AIDS-like pathologies: failure to thrive/weight loss, diarrhea, wasting, premature death, thymus atrophy, loss of CD4+ T cells, interstitial pneu...
Topics
- Acquired Immunodeficiency Syndrome
- Animals
- CD3 Complex
- Cell Cycle Proteins
- DNA, Viral
- Erythrocyte Count
- F-Box Proteins
- F-Box-WD Repeat-Containing Protein 7
- Flow Cytometry
- Gene Expression Regulation, Viral
- Gene Products, nef
- Genes, Viral
- HIV-1
- In Situ Hybridization
- Leukocyte Count
- Lymphoid Tissue
- Mice
- Mice, Transgenic