Article

Humanized Bone Marrow-Liver-Thymus Mice for Studying HIV-1 Persistence in Liver and Lung CD4+ T and Myeloid Cell Subsets during Antiretroviral Therapy

2025-02-06

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> While the role of CD4 + T-cells in HIV-1 reservoir persistence during antiretroviral therapy (ART) is well-established, studies on tissue-resident macrophages (MΦ) in people with HIV-1 (PWH) are restricted by difficulties in accessing deep tissue samples. Investigations in myeloid-only humanized mouse models demonstrated the contribution of MΦ to viral rebound upon ART inte...

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Literature Corpus work: 02ffd78c-83cd-50ac-84d6-7bfdd9f51bd4
DOI: 10.1101/2025.01.31.635552

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Humanized Bone Marrow-Liver-Thymus Mice for Studying HIV-1 Persistence in Liver and Lung CD4+ T and Myeloid Cell Subsets during Antiretroviral TherapyDOI 10.1101/2025.01.31.635552Read

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