Article

Presenilin-dependent regulation of tau pathology via the autophagy/proteasome pathway

2023-12-23

Abstract excerpt

Autosomal dominant inherited mutations in the presenilin ( PS / PSEN ) genes cause early-onset familial Alzheimer’s disease (AD) by enhancing cerebral accumulation of amyloid-β (Aβ) and microtubule-associated protein tau, although the precise cellular mechanisms by which PS dysfunction drives neuronal tau pathology remain still unclear. Here, we investigated the mechanisms linking PS/γ-secretase-dependent tau pa...

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Literature Corpus work: a3212b08-62cc-53e7-952b-8deabd38e87d
DOI: 10.1101/2023.12.21.572822

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