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Article

Presenilin 1 deficiency suppresses autophagy in human neural stem cells through reducing γ-secretase-independent ERK/CREB signaling.

Cell death & disease - 29 Aug 2018

Chong Cheong-Meng, Ke Minjing, Tan Yuan, Huang Zhijian, Zhang Ke, Ai Nana, Ge Wei, Qin Dajiang, Lu Jia-Hong, Su Huanxing

Abstract excerpt

Autophagy impairment is commonly implicated in the pathological characteristic of Alzheimer's disease (AD). Presenilin 1 (PS1) expression in human brain gradually decreases with age and its mutations account for the most common cases of early-onset familial Alzheimer's disease (FAD). The dominant autophagy phenotypes occur in PS1-knockout and PS1 mutant neurons; it is still unknown whether PS1 deficiency causes...

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PMID: 30158533
DOI: 10.1038/s41419-018-0945-7
PMCID: PMC6115391

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TFEB

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