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Article

Presenilin-dependent regulation of neuronal tau pathology via the autophagy and proteasome pathways.

Acta neuropathologica communications - 20 Mar 2026

Del Ser-Badia Anna, Soto-Faguás Carlos M, Vecino Rebeca, Vendrell Carles, Molina-Porcel Laura, Sánchez-Valle Raquel, Rodríguez-Alvarez José, Vicario Carlos, Saura Carlos A

Abstract excerpt

Mutations in the presenilin (PS/PSEN) genes cause early-onset familial Alzheimer's disease (AD) by enhancing cerebral accumulation of amyloid-β (Aβ) peptides and microtubule-associated protein tau (MAPT). How PS mutations affect Aβ generation is well characterized, but the precise cellular mechanisms by which PS dysfunction drives neuronal tau pathology are not fully understood. Here, we investigated the...

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Identifiers

PMID: 41863024
DOI: 10.1186/s40478-026-02270-6
PMCID: PMC13126707

Genes

PSEN1
MAPT

Variants

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