Article
Neurons derived from sporadic Alzheimer's disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation.
Alzheimer's research & therapy - 1 Dec 2017
Ochalek Anna, Mihalik Balázs, Avci Hasan X, Chandrasekaran Abinaya, Téglási Annamária, Bock István, Giudice Maria Lo, Táncos Zsuzsanna, Molnár Kinga, László Lajos, Nielsen Jørgen E, Holst Bjørn, Freude Kristine, Hyttel Poul, Kobolák Julianna, Dinnyés András
Abstract excerpt
BACKGROUND: Alzheimer's disease (AD) is the most common type of dementia, affecting one in eight adults over 65 years of age. The majority of AD cases are sporadic, with unknown etiology, and only 5% of all patients with AD present the familial monogenic form of the disease. In the present study, our aim was to establish an in vitro cell model based on patient-specific human neurons to study the pathomechanism of...
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