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Article

Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway.

The Journal of cell biology - 27 Sept 2004

Esselens Cary, Oorschot Viola, Baert Veerle, Raemaekers Tim, Spittaels Kurt, Serneels Lutgarde, Zheng Hui, Saftig Paul, De Strooper Bart, Klumperman Judith, Annaert Wim

Abstract excerpt

Presenilin 1 (PS1) interacts with telencephalin (TLN) and the amyloid precursor protein via their transmembrane domain (Annaert, W.G., C. Esselens, V. Baert, C. Boeve, G. Snellings, P. Cupers, K. Craessaerts, and B. De Strooper. 2001. Neuron. 32:579-589). Here, we demonstrate that TLN is not a substrate for gamma-secretase cleavage, but displays a prolonged half-life in PS1(-/-) hippocampal neurons. TLN...

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PMID: 15452145
DOI: 10.1083/jcb.200406060
PMCID: PMC2172014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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