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Age-related changes in tau and autophagy in human brain in the absence of neurodegeneration

26 Jan 2023

Abstract excerpt

Tau becomes abnormally hyper-phosphorylated and aggregated in tauopathies like Alzheimers disease (AD). As age is the greatest risk factor for developing AD, it is important to understand how tau protein itself, and the pathways implicated in its turnover, change during aging. We investigated age-related changes in total and phosphorylated tau in brain samples from two cohorts of cognitively normal individuals...

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PMID: 36701399
DOI: 10.1371/journal.pone.0262792

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