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Article

Autophagy impairment stimulates PS1 expression and γ-secretase activity

1 Apr 2010

Abstract excerpt

Gamma-secretase plays an important role in the development of Alzheimer disease (AD). Gamma-secretase activity is enriched in autophagic vacuoles and it augments amyloid-beta (Abeta) synthesis. Autophagy-lysosomal dysfunction has been implicated in AD, but whether gamma-secretase activity is affected by autophagy remains unclear. Here we report that gamma-secretase activity is enhanced in basal...

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PMID: 20168091
DOI: 10.4161/auto.6.3.11228

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