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Spike-in probe-enhanced single-cell RNA-seq reveals post-infusion transcriptomic remodeling of “prime-and-kill” synNotch-CAR-T cells

2026-03-29

Abstract excerpt

We previously developed synthetic Notch (synNotch)-chimeric antigen receptor (CAR)-T cells to improve the safety and efficacy of CAR-T therapy for glioblastoma. In this system, an anti-EphA2/IL13Rα2-dual-CAR is expressed only upon recognition of tumor- or brain-specific “priming” antigens, EGFRvIII (termed E-SYNC cells) or brevican (B-SYNC), respectively, with E-SYNC currently under phase I clinical evaluation (...

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Literature Corpus work
a314c5a5-0ca0-5d44-aca0-411e0386bf0b
DOI
10.64898/2026.03.26.713760
Open publication

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Spike-in probe-enhanced single-cell RNA-seq reveals post-infusion transcriptomic remodeling of “prime-and-kill” synNotch-CAR-T cellsDOI 10.64898/2026.03.26.713760
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