Article

Post-translational covalent assembly of CAR and synNotch receptors for programmable antigen targeting

2020-01-17

Abstract excerpt

Chimeric antigen receptors (CARs) and synthetic Notch (synNotch) receptors are engineered cell-surface receptors that sense a target antigen and respond by activating T cell receptor signaling or a customized gene program, respectively. To expand the targeting capabilities of these receptors, we have developed switchable adaptor receptor systems for which receptor specificity can be directed post-translationally v...

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Literature Corpus work: 713ede5c-2587-5c8f-9c24-c381208c8671
DOI: 10.1101/2020.01.17.909895

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