Article

Enhanced Solid Tumor Recognition and T cell Stemness with SynNotch CAR Circuits

2021-01-07

Abstract excerpt

<h4>ABSTRACT</h4> The lack of highly tumor-specific antigens limits the development of engineered T cell therapeutics because of life-threatening “on-target/off-tumor” toxicities. Here we identify ALPPL2 as a tumor-specific antigen expressed in a spectrum of solid tumors, including mesothelioma. ALPPL2 can act as a sole target for chimeric antigen receptor (CAR) therapy or be combined with tumor-associated antige...

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Identifiers and source

Literature Corpus work: acbb8a4f-8585-561f-8604-0181566d0192
DOI: 10.1101/2021.01.06.425642

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