Article

CSF single-cell RNA sequencing reveals clonally expanded CD4 <sup>+</sup> stem cell-like memory T cells in GAD65-antibody associated neurological syndromes

2025-05-22

Abstract excerpt

<h4>Background</h4> Glutamic acid decarboxylase (GAD) antibody-associated autoimmune neurological syndromes (AINS) are a spectrum of autoimmune-mediated CNS disorders. While antibodies targeting the 65 kDa isoform of GAD are of high diagnostic value, T cell mediated cytotoxicity has been identified as a key component of disease pathogenesis. The precise pathophysiological mechanisms by which the disease is trigge...

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Literature Corpus work: 4a2680ef-bd94-50c6-9115-b9d6b1bc6d37
DOI: 10.1101/2025.05.18.654720

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