Article

T cell circuits that sense antigen density with an ultrasensitive threshold

2021-01-21

Abstract excerpt

Overexpressed tumor associated antigens (e.g. HER2 and EGFR) are attractive targets for therapeutic T cells, but toxic cross-reaction with normal tissues expressing low antigen levels has been observed with Chimeric Antigen Receptor (CAR) T cells targeting such antigens. Inspired by natural ultrasensitive response circuits, we engineer a two-step positive feedback circuit that allows T cells to discriminate target...

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Literature Corpus work: 933023c6-b5c5-5cc4-bdcb-f85cc3d36fd0
DOI: 10.1101/2021.01.21.427654

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