Article

An <i>in situ</i> atlas of mitochondrial DNA in mammalian tissues reveals high content in stem/progenitor cells

2019-12-19

Abstract excerpt

<h4>ABSTRACT</h4> Mitochondria regulate ATP production, metabolism and cell death. Alterations in mitochondrial DNA (mtDNA) sequence and copy number are implicated in aging and organ dysfunction in diverse inherited and sporadic diseases. Since most measurements of mtDNA use homogenates of complex tissues, little is known about cell type-specific mtDNA copy number heterogeneity in normal physiology, aging and dis...

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Literature Corpus work: a30f7824-7ca5-5274-a0a1-29e14a446c7e
DOI: 10.1101/2019.12.19.876144

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