Nanobiopsy investigation of the subcellular mtDNA heteroplasmy in human tissues

Abstract excerpt

<title>Abstract</title> <p>Mitochondrial function is critical to continued cellular vitality and is an important contributor to a growing number of human diseases. Mitochondrial dysfunction is typically heterogeneous, mediated through the clonal expansion of mitochondrial DNA (mtDNA) variants in a subset of cells in a given tissue. To date, our understanding of the dynamics of clonal expansion of mtDNA variants h...

Topics

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• Clonal Evolution
• DNA, Mitochondrial
• Heteroplasmy
• High-Throughput Nucleotide Sequencing
• Mitochondria
• Mitochondrial Diseases
• Mutation
• Single-Cell Analysis

Identifiers and source

Literature Corpus work

5931a493-9607-5966-b014-8b04d32df686

DOI

10.21203/rs.3.rs-3097042/v1