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Article

Thinking outside the nucleus: Mitochondrial DNA copy number in health and disease.

Mitochondrion - 1 Jul 2020

Castellani Christina A, Longchamps Ryan J, Sun Jing, Guallar Eliseo, Arking Dan E

Abstract excerpt

Mitochondrial DNA copy number (mtDNA-CN) is a biomarker of mitochondrial function and levels of mtDNA-CN have been reproducibly associated with overall mortality and a number of age-related diseases, including cardiovascular disease, chronic kidney disease, and cancer. Recent advancements in techniques for estimating mtDNA-CN, in particular the use of DNA microarrays and next-generation sequencing data, have led...

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Identifiers

PMID: 32544465
DOI: 10.1016/j.mito.2020.06.004
PMCID: PMC7375936

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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