Article

Brain-body mitochondrial distribution patterns lack coherence and point to tissue-specific and individualized regulatory mechanisms

2024-09-22

Abstract excerpt

Energy transformation capacity is generally assumed to be a coherent individual trait driven by genetic and environmental factors. This predicts that some individuals should have high and others low mitochondrial oxidative phosphorylation (OxPhos) capacity across organ systems. Here, we test this assumption using multi-tissue molecular and enzymatic activities in mice and humans. Across up to 22 mouse tissues, nei...

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Literature Corpus work: 7069ec84-d0d1-5115-85a5-543ef45746d9
DOI: 10.1101/2024.09.20.614152

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