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Article

Nanobiopsy investigation of the subcellular mtDNA heteroplasmy in human tissues.

Scientific reports - 14 Jun 2024

Bury Alexander, Pyle Angela, Vincent Amy E, Actis Paolo, Hudson Gavin

Abstract excerpt

Mitochondrial function is critical to continued cellular vitality and is an important contributor to a growing number of human diseases. Mitochondrial dysfunction is typically heterogeneous, mediated through the clonal expansion of mitochondrial DNA (mtDNA) variants in a subset of cells in a given tissue. To date, our understanding of the dynamics of clonal expansion of mtDNA variants has been technically limited...

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Identifiers

PMID: 38877095
DOI: 10.1038/s41598-024-64455-0
PMCID: PMC11178779

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