Article

Age-related and heteroplasmy-related variation in human mtDNA copy number

2015-10-29

Abstract excerpt

The mitochondrial (mt) genome is present in many copies in human cells, and intra-individual variation in mtDNA sequences is known as heteroplasmy. Recent studies found that heteroplasmies are highly tissue-specific, site-specific, and allele-specific, however the functional implications have not been explored. This study investigates variation in mtDNA copy numbers (mtCN) in 12 different tissues obtained at autop...

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Literature Corpus work: 4237fd0f-003f-5c3c-b270-3c9a8ea9d39a
DOI: 10.1101/030205

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