Article

Subunit-specific roles of LRRC8 proteins in determining glutamate permeability of astrocytic volume-regulated anion channels

2025-07-29

Abstract excerpt

<h4>ABSTRACT</h4> Volume-regulated anion channels (VRACs) are ubiquitous chloride channels that play important roles in cell volume regulation and numerous other physiological processes. VRACs are heteromeric complexes composed of leucine-rich repeat-containing proteins LRRC8A-E. LRRC8 subunit composition determines biophysical properties of VRACs, including permeability to small signaling molecules. Here, we use...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a2fdaf38-b784-51c5-83bc-a276b03c293a
DOI: 10.1101/2025.07.24.666608

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Subunit-specific roles of LRRC8 proteins in determining glutamate permeability of astrocytic volume-regulated anion channelsDOI 10.1101/2025.07.24.666608Read

Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC.Semantic proximity Read

A neuropsychiatric disease-associated mutation in LRRC8B disrupts cellular Ca²⁺ signaling, mitochondrial function, and bioenergeticsSemantic proximity Read

Leucine-rich repeat containing protein LRRC8A is essential for swelling-activated Cl− currents and embryonic development in zebrafishSemantic proximity Read

Spinal cord pathology in a Dravet Syndrome mouse modelSemantic proximity Read

MLC1: A New Calcium-regulated Protein Conferring Calcium Dependence to Volume-regulated Anion Channels (VRAC) in Astrocytes.Semantic proximity Read

LRRK2 G2019S disrupts GABAergic signaling and shifts excitatory/inhibitory balance in the striatumSemantic proximity Read

Deletion of LRP1 From Astrocytes Modifies Neuronal Network Activity in an in vitro Model of the Tripartite SynapseSemantic proximity Read

Trafficking of the glutamate transporter is impaired in LRRK2-related Parkinson’s diseaseSemantic proximity Read

Trafficking of the glutamate transporter is impaired in LRRK2-related Parkinson's disease.Semantic proximity Read

Insights into MLC pathogenesis: GlialCAM is an MLC1 chaperone required for proper activation of volume-regulated anion currents.Semantic proximity Read

Structure of the human volume regulated anion channelSemantic proximity Read

Identification of the GlialCAM interactome: the G protein-coupled receptors GPRC5B and GPR37L1 modulate megalencephalic leukoencephalopathy proteins.Semantic proximity Read