Article

MLC1: A New Calcium-regulated Protein Conferring Calcium Dependence to Volume-regulated Anion Channels (VRAC) in Astrocytes.

2022-01-03

Abstract excerpt

<title>Abstract</title> <p>MLC1 is a membrane protein highly expressed by brain perivascular astrocytes. Mutations in the MLC1 gene account for megalencephalic leukoencephalopathy with subcortical cysts (MLC), an incurable leukodystrophy characterized by macrocephaly, brain edema and cysts, myelin vacuolation and astrocyte swelling, causing cognitive and motor dysfunctions. It has been demonstrated that MLC1 muta...

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Literature Corpus work: 57473825-b175-59e3-86d7-774b5d873e4f
DOI: 10.21203/rs.3.rs-1195518/v1

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