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Leucine-rich repeat containing protein LRRC8A is essential for swelling-activated Cl− currents and embryonic development in zebrafish

28 Sept 2016

Abstract excerpt

A volume-regulated anion channel (VRAC) has been electrophysiologically characterized in innumerable mammalian cell types. VRAC is activated by cell swelling and mediates the volume regulatory efflux of Cl(-) and small organic solutes from cells. Two groups recently identified the mammalian leucine-rich repeat containing protein LRRC8A as an essential VRAC component. LRRC8A must be coexpressed with at least one...

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PMID: 27688432
DOI: 10.14814/phy2.12940

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