Article

Comparison of induced neurons reveals slower structural and functional maturation in humans than in apes

2020-05-24

Abstract excerpt

<h4>ABSTRACT</h4> We generated induced excitatory sensory neurons (iNeurons, iNs) from chimpanzee, bonobo and human stem cells by expressing the transcription factor neurogenin-2 (NGN2). Single cell-RNA sequencing showed that genes involved in dendrite and synapse development are expressed earlier during iNs maturation in the chimpanzee than the human cells. In accordance, during the first two weeks of differenti...

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Literature Corpus work: 5b9b58fc-a16e-5fdf-be72-7a59f8c3f54c
DOI: 10.1101/2020.05.21.094912

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