Article

Correcting for effect modification in the doubly-ranked non-linear Mendelian randomization method

2026-01-23

Abstract excerpt

The doubly-ranked non-linear Mendelian randomization method can yield biased estimates when instrument strength varies across individuals due to gene-environment (GxE) interactions. We propose a simple strategy to mitigate this bias by modelling GxE interactions and removing the fitted GxE component from the exposure before stratification by the doubly-ranked method. In simulations, the proposed GxE correction str...

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Literature Corpus work: a2d3806d-ab78-56b2-9cae-16a144439458
DOI: 10.64898/2026.01.22.26344640

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