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Article

Sensitivity Analyses for Robust Causal Inference from Mendelian Randomization Analyses with Multiple Genetic Variants.

Epidemiology (Cambridge, Mass.) - 1 Jan 2017

Burgess Stephen, Bowden Jack, Fall Tove, Ingelsson Erik, Thompson Simon G

Abstract excerpt

Mendelian randomization investigations are becoming more powerful and simpler to perform, due to the increasing size and coverage of genome-wide association studies and the increasing availability of summarized data on genetic associations with risk factors and disease outcomes. However, when using multiple genetic variants from different gene regions in a Mendelian randomization analysis, it is highly...

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PMID: 27749700
DOI: 10.1097/EDE.0000000000000559
PMCID: PMC5133381

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