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Article

Relaxing parametric assumptions for non-linear Mendelian randomization using a doubly-ranked stratification method

30 Jun 2023

Abstract excerpt

Non-linear Mendelian randomization is an extension to standard Mendelian randomization to explore the shape of the causal relationship between an exposure and outcome using an instrumental variable. A stratification approach to non-linear Mendelian randomization divides the population into strata and calculates separate instrumental variable estimates in each stratum. However, the standard implementation of...

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PMID: 37390109
DOI: 10.1371/journal.pgen.1010823

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